Topic: The comparison between physical and chemical
adsorption of HA coating on nanotubular anodized Ti-28Nb-11Ta-8Zr alloy
Abstract:
Based on the former research, we would like to process some surface treatment on Ti-28Nb-11Ta-8Zr alloy (TNTZ) which is utilized to reduce elastic modulus to reach the bone-memetic condition without losing biocompatibility and further improves corrosion resistance in the body fluid. Besides, to mimic nano-sized porous structure on bone extracellular matrix (ECM) for cell interlocks, surface modification was carried out by anodic oxidation (AO) to manufacture amorphous nanoporous oxide coating with the characteristics of highly adhesive coating, chemical inert and rough surface morphology to serve as the study goal. To strength the cell activity, we try to doped HA into TNTZO in different ways and process drug-releasing in Simulated Body Fluid (SBF) solution to show the effect by changing the process. Through the cell test and low-temperature drying, we can observe the the cell shape by SEM in different drug-releasing periods. With this experiment, we can directly observe the cell changing in the most similar environment.
Based on the former research, we would like to process some surface treatment on Ti-28Nb-11Ta-8Zr alloy (TNTZ) which is utilized to reduce elastic modulus to reach the bone-memetic condition without losing biocompatibility and further improves corrosion resistance in the body fluid. Besides, to mimic nano-sized porous structure on bone extracellular matrix (ECM) for cell interlocks, surface modification was carried out by anodic oxidation (AO) to manufacture amorphous nanoporous oxide coating with the characteristics of highly adhesive coating, chemical inert and rough surface morphology to serve as the study goal. To strength the cell activity, we try to doped HA into TNTZO in different ways and process drug-releasing in Simulated Body Fluid (SBF) solution to show the effect by changing the process. Through the cell test and low-temperature drying, we can observe the the cell shape by SEM in different drug-releasing periods. With this experiment, we can directly observe the cell changing in the most similar environment.
Keywords:anodic
oxidation; Ti-Nb-Ta-Zr; nanopores; antibacterial ability; P. aeruginosa; MRSA;
osteoblasts
Experiment design:
- Pre-treatment: Polish the TNTZ surface and process anodic oxidation to create nanotube on TNTZ surface.
- Doped HA with Alternative immersion method(AIM): Divide process into physical and chemical adsorption , and use XPS, SEM to observer the diffrence between two methods.
Cell test: Immerse in Simulated Body Fluid (SBF) and observe the cell shape changing with the different HA concentration.